Download PDF She Has Her Mother's Laugh: The Powers, Perversions, and Potential of Heredity
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She Has Her Mother's Laugh: The Powers, Perversions, and Potential of Heredity
Download PDF She Has Her Mother's Laugh: The Powers, Perversions, and Potential of Heredity
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2019 PEN/E.O. Wilson Literary Science Writing Award Finalist
"Science book of the year" (The Guardian)
One of New York Times 100 notable books for 2018.
One of Publishers Weekly's top 10 books of 2018.
One of Kirkus' best books of 2018.
One of Mental Floss' best books of 2018.
One of Science Friday's best science books of 2018.
"Extraordinary" (New York Times Book Review)
"Magisterial" (The Atlantic)
"Engrossing" (Wired)
"Leading contender as the most outstanding nonfiction work of the year." (Minneapolis Star-Tribune)
Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation.Â
Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities....
But, Zimmer writes, "Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are - our appearance, our height, our penchants - in inconceivably subtle ways."
Heredity isn't just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors - using a word that once referred to kingdoms and estates - but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable.
We need a new definition of what heredity is, and, through Carl Zimmer's lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world's best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies but also longstanding presumptions about who we really are and what we can pass on to future generations.
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Audible Audiobook
Listening Length: 20 hours and 32 minutes
Program Type: Audiobook
Version: Unabridged
Publisher: Penguin Audio
Audible.com Release Date: May 29, 2018
Whispersync for Voice: Ready
Language: English, English
ASIN: B07B5324LW
Amazon Best Sellers Rank:
Public understanding of heredity has profound consequences for many dimensions, including research funding, toxicology, medicine, regulation, and even warfare. For example, warped views of heredity fueled ideologies that killed tens of millions in WWII and more recently has funneled the bulk of precious research dollars into the ridiculously shallow box of genetic causation for today's public health crises. Because our limited views of heredity need a sweeping update, I give this book 5 stars for its scope, ambition, and exquisite quality of execution. It takes us a solid step in the right direction, and will greatly enrich public dialogue.Sadly, the book does falter in one key area—Zimmer's weak treatment of epigenetic inheritance. First, he mistakenly calls it a "new flavor of Lamarckism," which is incorrect. The research in this area largely involves direct exposures to early germ cells, and the heritable consequences thereof, and not with some fluffy idea about "acquired characteristics" wending their way into the germline. Moreover, while Zimmer briefly mentions nutrition, plasticizers, and pesticides as exposures that may influence nongenetic germline-borne heredity, he altogether ignores the compelling and deeply troubling evidence of generational pathology caused by the toxic pregnancy drug diethylstilbestrol (DES). How he could have overlooked heritable consequences of the greatest medical catastrophe of our age, yet decide to devote 2/3 of a page to an uber-skeptic like Kevin Mitchell is beyond me. But fear not, good readers, the other 99.99% of the book is outstanding and deserves your attention.
Herr Zimmer does it again !- I have been his fan since his earlier book on E coli .Average reader without Biology background need not get intimidated by length of the book . The book reads like a well crafted Novel.He explains complex concepts in very simple words interspersed with human interest stories.This book covers new material and has a different approach compared to Dr. Siddhartha Mukherjee's popular book .The extensive Bibliography is helpful for further reading.This work represents Science writing at its Best.
My rating of the book is 4 out of 5. It is not quite clear for what group of people it was written: a little too complex and lacking illustrations for generalists and a little too generalized for experts. I agree with the reviewer who suggests that a potential purchaser/reader might want to look at some parts of an electronic version to be able to form an opinion if the book is for him/her. What I found most surprising in the existing reviews is that nobody seems to address the content of Part V, the development and usage of CRISPR and related technology. It has the potential of changing humanity for better or for worse and it is up to humans to decide which direction to take, in a general way as the decision or lack of it to control earth’s surface temperature. It is a subject that should be studied and discussed much more by the general public that can learn about it in this book.
I'm not a professional academic - purchased based on an amazing consensus of notable biologists recommends. I was not disappointed other than the fact that it finally ended in Chapter 19. Kept wanting more. To me it is the history and future of life on our planet. I'm in my late 60's. The ground Zimmer covers in his historical narratives struck me personally as amazing. Such a diverse accounting of past personnages. I figured that Pearl S. Buck could never play a part in such a book: SURPRISE ! But the up-to-date timeliness is really what makes it so important . Hope one gets to read it and give to younger folk as it's lessons are vital for a proper perspective on future progeny. Wife and I already purchased and gave away to 4 couples in the 30's age group.
Some books just grip you by the throat and won't let go. This one does that. But in a nice way.I was just going to look something up that I had read about in a book review in New Scientist, and then I just couldn't stop.Incredibly interesting material, and told in a way that on top of the enjoyment and delight I feel, I also feel a sting of jealousy. Oh man how I wish I could write like that. Superior storytelling, it's at the level of, and at times surpasses that of Malcolm Gladwell due to the mastery of such an interesting area.Enjoy!From an avidly reading doctor
The science would be SO much easier to understand if accompanied by drawings and diagrams. There are NONE in this book. Well written with fascinating stories.
Many years have passed since my first lesson in genetics was a black and white movie of Theodosius Dobzhansky explaining the basics of genetics. A lot has changed since then! Carl Zimmer’s recent book She Has Her Mother’s Laugh can bring everyone up to date even if they started learning about genetics long after Dr. Dobzhansky died in 1975.Although Zimmer’s detailed telling of the story of hereditary is a wonderful read for me 3 areas were outstanding and explained clearly: 1. the obsession of European royalty with blood lines and the problems it led to as typified by the Habsburgs, 2. Epigenetics and how genes can be turned on and off, including how diet and pollutants can affect the epigenome and 3. CRISPR mechanism that enables CRISPR produced enzymes to bind to a specific DNA segment, cut it and thus shutting off the gene.Dr. Dobzhansky would find this book an enlightening read of everything that has happened since his death, I did and you will too.
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